Drug interactions
Levodopa + Sapropterin
Severity: Moderate
Levodopa and Sapropterin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concomitant use has been associated with neurologic events such as seizures, exacerbated seizures, over-stimulation and irritability. The cause is not clearly established.
What this interaction means in plain words
Levodopa and Sapropterin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levodopa belongs to Central Nervous System; Sapropterin belongs to Miscellaneous.
Why it happens
Mechanism not established; possible effects on catecholamine neurotransmitter synthesis since sapropterin is a cofactor for tyrosine hydroxylase.
What to do
Monitor neurologic status, including seizures and agitation, during combined use. Adjust the dose of either drug if events occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sapropterin
- Avanafil + Sapropterin Moderate
- Carbidopa-entacapone-levodopa + Sapropterin Moderate
- Carbidopa-levodopa + Sapropterin Moderate
- Methotrexate + Sapropterin Moderate
- Phenobarbitone + Sapropterin Moderate
- Pyrimethamine + Sapropterin Moderate
Other interactions of Levodopa
- Isocarboxazid + Levodopa Contraindicated
- Levodopa + Phenelzine Contraindicated
- Levodopa + Phenelzine (nonselective MAOI) Contraindicated
- Levodopa + Procarbazine Contraindicated
- Levodopa + Tranylcypromine Contraindicated
- Amisulpride + Levodopa Major
Frequently asked questions
Can I take Levodopa with Sapropterin?
MediHelp rates the interaction as moderate. Levodopa and Sapropterin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concomitant use has been associated with neurologic events such as seizures, exacerbated seizures, over-stimulation and irritability. The cause is not clearly established.
How serious is the interaction between Levodopa and Sapropterin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neurologic status, including seizures and agitation, during combined use. Adjust the dose of either drug if events occur.
What other medicines interact with Sapropterin?
MediHelp also lists interactions of Sapropterin with, for example, Avanafil, Carbidopa-entacapone-levodopa, Carbidopa-levodopa. The full list is on the Sapropterin page.
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