Drug interactions
Saquinavir + Sofosbuvir-velpatasvir
Severity: Minor
Saquinavir and Sofosbuvir-velpatasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saquinavir, usually boosted by ritonavir, inhibits CYP3A4 and P-gp and may raise velpatasvir exposure. Saquinavir also prolongs QT, but velpatasvir itself carries no major QT concern.
What this interaction means in plain words
Saquinavir and Sofosbuvir-velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Saquinavir inhibits CYP3A4 and P-gp, reducing velpatasvir clearance.
What to do
No velpatasvir dose change is needed. Monitor ECG as indicated for saquinavir.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Saquinavir and Sofosbuvir-velpatasvir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Frequently asked questions
Can I take Saquinavir with Sofosbuvir-velpatasvir?
MediHelp rates the interaction as minor. Saquinavir and Sofosbuvir-velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Saquinavir, usually boosted by ritonavir, inhibits CYP3A4 and P-gp and may raise velpatasvir exposure. Saquinavir also prolongs QT, but velpatasvir itself carries no major QT concern.
How serious is the interaction between Saquinavir and Sofosbuvir-velpatasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No velpatasvir dose change is needed. Monitor ECG as indicated for saquinavir.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
