Drug interactions
Saquinavir + Timolol
Severity: Moderate
Saquinavir and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saquinavir can prolong the PR and QT intervals, and combining it with a beta-blocker that slows AV conduction may increase the risk of conduction block or bradyarrhythmia. The risk is higher with systemic timolol and in patients with underlying conduction disease.
What this interaction means in plain words
Saquinavir and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effects on AV nodal conduction from beta-blockade and saquinavir-induced PR prolongation.
What to do
Obtain a baseline ECG and monitor PR interval and heart rate if used together. Consider an alternative to the beta-blocker in patients with conduction abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Saquinavir with Timolol?
MediHelp rates the interaction as moderate. Saquinavir and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Saquinavir can prolong the PR and QT intervals, and combining it with a beta-blocker that slows AV conduction may increase the risk of conduction block or bradyarrhythmia. The risk is higher with systemic timolol and in patients with underlying conduction disease.
How serious is the interaction between Saquinavir and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor PR interval and heart rate if used together. Consider an alternative to the beta-blocker in patients with conduction abnormalities.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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