Drug interactions
Saquinavir + Valsartan
Severity: Minor
Saquinavir and Valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saquinavir may inhibit hepatic transporters involved in valsartan uptake, potentially increasing valsartan exposure. This could cause hypotension or renal effects, though clinical data are limited.
What this interaction means in plain words
Saquinavir and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of OATP1B1-mediated hepatic uptake of valsartan.
What to do
Monitor blood pressure and renal function when starting saquinavir and reduce the valsartan dose if hypotension develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Saquinavir with Valsartan?
MediHelp rates the interaction as minor. Saquinavir and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Saquinavir may inhibit hepatic transporters involved in valsartan uptake, potentially increasing valsartan exposure. This could cause hypotension or renal effects, though clinical data are limited.
How serious is the interaction between Saquinavir and Valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function when starting saquinavir and reduce the valsartan dose if hypotension develops.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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