Drug interactions
Saw palmetto + Tolmetin
Severity: Minor
Saw palmetto and Tolmetin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saw palmetto has been associated with isolated reports of bleeding and may have mild antiplatelet activity. Combined with an NSAID such as tolmetin, bleeding risk could theoretically increase.
What this interaction means in plain words
Saw palmetto and Tolmetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Saw palmetto belongs to Gastrointestinal Tract; Tolmetin belongs to Musculoskeletal.
Why it happens
Possible additive effect on platelet function; the mechanism is not well established.
What to do
Ask patients about herbal use and advise them to report unusual bruising or bleeding. Consider stopping saw palmetto if bleeding signs develop or before surgery.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Saw palmetto
- Aspirin rectal + Saw palmetto Moderate
- Aspirin + Saw palmetto Moderate
- Dabigatran + Saw palmetto Moderate
- Desirudin + Saw palmetto Moderate
- Ketorolac + Saw palmetto Moderate
- Meclofenamate + Saw palmetto Moderate
Frequently asked questions
Can I take Saw palmetto with Tolmetin?
MediHelp rates the interaction as minor. Saw palmetto and Tolmetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Saw palmetto has been associated with isolated reports of bleeding and may have mild antiplatelet activity. Combined with an NSAID such as tolmetin, bleeding risk could theoretically increase.
How serious is the interaction between Saw palmetto and Tolmetin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients about herbal use and advise them to report unusual bruising or bleeding. Consider stopping saw palmetto if bleeding signs develop or before surgery.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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