Drug interactions
Scopolamine + Thiothixene
Severity: Moderate
Scopolamine and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiothixene has anticholinergic properties that add to scopolamine, raising the risk of dry mouth, constipation, urinary retention, blurred vision and confusion. Anticholinergic slowing of gut motility may also modestly alter oral absorption of the antipsychotic.
What this interaction means in plain words
Scopolamine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic blockade, with possible reduced gastrointestinal absorption through slowed motility.
What to do
Monitor for anticholinergic adverse effects and for loss of antipsychotic response; use the lowest effective doses, especially in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Scopolamine
Frequently asked questions
Can I take Scopolamine with Thiothixene?
MediHelp rates the interaction as moderate. Scopolamine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiothixene has anticholinergic properties that add to scopolamine, raising the risk of dry mouth, constipation, urinary retention, blurred vision and confusion. Anticholinergic slowing of gut motility may also modestly alter oral absorption of the antipsychotic.
How serious is the interaction between Scopolamine and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and for loss of antipsychotic response; use the lowest effective doses, especially in older patients.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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