Drug interactions
Scopolamine + Trifluoperazine
Severity: Moderate
Scopolamine and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trifluoperazine has some anticholinergic activity that adds to scopolamine, increasing the chance of dry mouth, constipation, urinary retention, blurred vision and confusion. Reduced gut motility may also change oral absorption of the antipsychotic, and heat intolerance is a concern.
What this interaction means in plain words
Scopolamine and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic blockade, with possible altered absorption due to slowed gastrointestinal motility.
What to do
Monitor for anticholinergic adverse effects and for reduced antipsychotic effect; minimize doses and avoid in patients with glaucoma or urinary obstruction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Scopolamine
Frequently asked questions
Can I take Scopolamine with Trifluoperazine?
MediHelp rates the interaction as moderate. Scopolamine and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trifluoperazine has some anticholinergic activity that adds to scopolamine, increasing the chance of dry mouth, constipation, urinary retention, blurred vision and confusion. Reduced gut motility may also change oral absorption of the antipsychotic, and heat intolerance is a concern.
How serious is the interaction between Scopolamine and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and for reduced antipsychotic effect; minimize doses and avoid in patients with glaucoma or urinary obstruction.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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