Drug interactions
Scopolamine + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Scopolamine and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Umeclidinium is an inhaled antimuscarinic and scopolamine is a systemic one. Combined use may cause additive anticholinergic effects such as dry mouth, urinary retention, constipation, blurred vision and raised intraocular pressure.
What this interaction means in plain words
Scopolamine and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic receptor blockade.
What to do
Monitor for anticholinergic effects, particularly urinary retention, constipation and glaucoma symptoms. Avoid in patients with narrow-angle glaucoma or urinary obstruction, or choose an alternative to scopolamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Scopolamine
Frequently asked questions
Can I take Scopolamine with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Scopolamine and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Umeclidinium is an inhaled antimuscarinic and scopolamine is a systemic one. Combined use may cause additive anticholinergic effects such as dry mouth, urinary retention, constipation, blurred vision and raised intraocular pressure.
How serious is the interaction between Scopolamine and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects, particularly urinary retention, constipation and glaucoma symptoms. Avoid in patients with narrow-angle glaucoma or urinary obstruction, or choose an alternative to scopolamine.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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