Drug interactions
Scopolamine + Umeclidinium bromide
Severity: Moderate
Scopolamine and Umeclidinium bromide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Umeclidinium is an inhaled long-acting muscarinic antagonist, and adding scopolamine may increase systemic anticholinergic effects. This can contribute to dry mouth, urinary retention, constipation, tachycardia and worsening of narrow-angle glaucoma.
What this interaction means in plain words
Scopolamine and Umeclidinium bromide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor blockade.
What to do
Avoid additional anticholinergic agents where possible; monitor for urinary retention, visual symptoms and constipation if both are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Scopolamine
Frequently asked questions
Can I take Scopolamine with Umeclidinium bromide?
MediHelp rates the interaction as moderate. Scopolamine and Umeclidinium bromide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Umeclidinium is an inhaled long-acting muscarinic antagonist, and adding scopolamine may increase systemic anticholinergic effects. This can contribute to dry mouth, urinary retention, constipation, tachycardia and worsening of narrow-angle glaucoma.
How serious is the interaction between Scopolamine and Umeclidinium bromide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid additional anticholinergic agents where possible; monitor for urinary retention, visual symptoms and constipation if both are used.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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