Drug interactions
Secretin + Tolterodine
Severity: Moderate
Secretin and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anticholinergic drugs can blunt the pancreatic and gastric response to secretin stimulation testing. This may produce falsely abnormal results and misdiagnosis.
What this interaction means in plain words
Secretin and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism, as anticholinergic action interferes with the secretory response being tested.
What to do
Hold tolterodine for several half-lives before secretin testing and restart afterwards.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Frequently asked questions
Can I take Secretin with Tolterodine?
MediHelp rates the interaction as moderate. Secretin and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anticholinergic drugs can blunt the pancreatic and gastric response to secretin stimulation testing. This may produce falsely abnormal results and misdiagnosis.
How serious is the interaction between Secretin and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold tolterodine for several half-lives before secretin testing and restart afterwards.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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