Drug interactions
Selegiline + Serdexmethylphenidate / dexmethylphenidate
Severity: Contraindicated
Selegiline and Serdexmethylphenidate / dexmethylphenidate: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors with methylphenidate-type stimulants can provoke hypertensive crisis. Labeling contraindicates use during MAOI therapy and for 14 days afterward.
What this interaction means in plain words
Selegiline and Serdexmethylphenidate / dexmethylphenidate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
The stimulant increases synaptic catecholamines, and MAO inhibition prevents their degradation.
What to do
Do not combine. Allow at least 14 days after stopping the MAOI before starting this product.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Selegiline with Serdexmethylphenidate / dexmethylphenidate?
MediHelp rates the interaction as contraindicated. Selegiline and Serdexmethylphenidate / dexmethylphenidate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. MAO inhibitors with methylphenidate-type stimulants can provoke hypertensive crisis. Labeling contraindicates use during MAOI therapy and for 14 days afterward.
How serious is the interaction between Selegiline and Serdexmethylphenidate / dexmethylphenidate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Allow at least 14 days after stopping the MAOI before starting this product.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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