Drug interactions
Selegiline + Sumatriptan intranasal
Severity: Moderate
Selegiline and Sumatriptan intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO-A inhibition raises sumatriptan exposure, and both have serotonergic effects. Serotonin syndrome is possible, although selegiline is selective for MAO-B at low oral doses.
What this interaction means in plain words
Selegiline and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects, with reduced sumatriptan metabolism when MAO-A is inhibited.
What to do
Monitor for serotonin toxicity symptoms. Avoid in patients on higher selegiline doses or transdermal selegiline where MAO-A inhibition is expected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Selegiline with Sumatriptan intranasal?
MediHelp rates the interaction as moderate. Selegiline and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO-A inhibition raises sumatriptan exposure, and both have serotonergic effects. Serotonin syndrome is possible, although selegiline is selective for MAO-B at low oral doses.
How serious is the interaction between Selegiline and Sumatriptan intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin toxicity symptoms. Avoid in patients on higher selegiline doses or transdermal selegiline where MAO-A inhibition is expected.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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