Drug interactions
Selegiline + Thiothixene
Severity: Moderate
Selegiline and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antipsychotics can enhance serotonergic toxicity, and dopamine blockade opposes the effect of selegiline in Parkinson disease. Thiothixene may worsen parkinsonism, and neuroleptic malignant syndrome is a rare risk.
What this interaction means in plain words
Selegiline and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing dopaminergic effects (D2 blockade versus MAO-B inhibition), with possible additive serotonergic effects.
What to do
Monitor motor function, mental status and temperature. Prefer an antipsychotic with less D2 blockade if parkinsonism is present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Selegiline with Thiothixene?
MediHelp rates the interaction as moderate. Selegiline and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antipsychotics can enhance serotonergic toxicity, and dopamine blockade opposes the effect of selegiline in Parkinson disease. Thiothixene may worsen parkinsonism, and neuroleptic malignant syndrome is a rare risk.
How serious is the interaction between Selegiline and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor function, mental status and temperature. Prefer an antipsychotic with less D2 blockade if parkinsonism is present.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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