Drug interactions
Selegiline + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Selegiline and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol is a long-acting beta2-agonist, and its cardiovascular effects such as tachycardia, palpitations and blood pressure changes can be amplified in patients taking MAO inhibitors. Selegiline at higher or non-selective doses, and especially the transdermal form, carries the greatest concern. The effect may persist for about two weeks after the MAO inhibitor is stopped.
What this interaction means in plain words
Selegiline and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
MAO inhibition raises adrenergic tone and may potentiate beta2-agonist cardiovascular stimulation.
What to do
Monitor heart rate, blood pressure and ECG symptoms when starting or adjusting the inhaler. Consider a non-beta-agonist bronchodilator alternative if cardiovascular effects appear, especially with transdermal selegiline.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Selegiline with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Selegiline and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol is a long-acting beta2-agonist, and its cardiovascular effects such as tachycardia, palpitations and blood pressure changes can be amplified in patients taking MAO inhibitors. Selegiline at higher or non-selective doses, and especially the transdermal form, carries the greatest concern. The effect may persist for about two weeks after the MAO inhibitor is stopped.
How serious is the interaction between Selegiline and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG symptoms when starting or adjusting the inhaler. Consider a non-beta-agonist bronchodilator alternative if cardiovascular effects appear, especially with transdermal selegiline.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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