Drug interactions
Selegiline + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Selegiline and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol is a long-acting beta2-agonist whose cardiovascular effects, including tachycardia and blood pressure changes, may be enhanced by MAO inhibitors. The concern persists for about two weeks after stopping the MAO inhibitor and is greatest with transdermal or higher-dose selegiline.
What this interaction means in plain words
Selegiline and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
MAO inhibition raises adrenergic tone and may potentiate beta2-agonist cardiovascular stimulation.
What to do
Monitor heart rate and blood pressure after starting or changing doses. Consider a non-beta-agonist alternative if significant cardiovascular effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Selegiline and Vilanterol / fluticasone furoate inhaled, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Selegiline with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Selegiline and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol is a long-acting beta2-agonist whose cardiovascular effects, including tachycardia and blood pressure changes, may be enhanced by MAO inhibitors. The concern persists for about two weeks after stopping the MAO inhibitor and is greatest with transdermal or higher-dose selegiline.
How serious is the interaction between Selegiline and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure after starting or changing doses. Consider a non-beta-agonist alternative if significant cardiovascular effects occur.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
