Drug interactions
Selumetinib + Tirofiban
Severity: Moderate
Selumetinib and Tirofiban: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selumetinib labeling notes increased bleeding risk with antiplatelet agents and vitamin K antagonists, and hemorrhage has occurred with the drug. Combined with tirofiban, bleeding risk is likely to be increased.
What this interaction means in plain words
Selumetinib and Tirofiban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Selumetinib belongs to Oncology; Tirofiban belongs to Cardiovascular.
Why it happens
Additive bleeding risk; selumetinib hemorrhagic effects are not fully explained and add to glycoprotein IIb/IIIa platelet inhibition.
What to do
Monitor for bleeding signs and hemoglobin during co-use. Reassess the need for the combination if bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tirofiban
Other interactions of Selumetinib
Frequently asked questions
Can I take Selumetinib with Tirofiban?
MediHelp rates the interaction as moderate. Selumetinib and Tirofiban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selumetinib labeling notes increased bleeding risk with antiplatelet agents and vitamin K antagonists, and hemorrhage has occurred with the drug. Combined with tirofiban, bleeding risk is likely to be increased.
How serious is the interaction between Selumetinib and Tirofiban?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs and hemoglobin during co-use. Reassess the need for the combination if bleeding occurs.
What other medicines interact with Tirofiban?
MediHelp also lists interactions of Tirofiban with, for example, Abrocitinib, Acalabrutinib, Acetylsalicylic acid. The full list is on the Tirofiban page.
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