Drug interactions
Shepherd's purse + Spironolactone
Severity: Minor
Shepherd's purse and Spironolactone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Shepherd's purse has been reported to have effects on blood pressure and uterine tone, though the data are limited. It could theoretically blunt the blood pressure lowering effect of spironolactone. Clinical evidence of a real interaction is lacking.
What this interaction means in plain words
Shepherd's purse and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical pharmacodynamic opposition on blood pressure; no established mechanism.
What to do
Advise patients taking spironolactone for hypertension to avoid shepherd's purse products. Check blood pressure if use is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Shepherd's purse with Spironolactone?
MediHelp rates the interaction as minor. Shepherd's purse and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Shepherd's purse has been reported to have effects on blood pressure and uterine tone, though the data are limited. It could theoretically blunt the blood pressure lowering effect of spironolactone. Clinical evidence of a real interaction is lacking.
How serious is the interaction between Shepherd's purse and Spironolactone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients taking spironolactone for hypertension to avoid shepherd's purse products. Check blood pressure if use is started.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
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