Drug interactions
Sildenafil + Timolol
Severity: Minor
Sildenafil and Timolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic timolol (including some absorption from eye drops) may add to sildenafil's blood pressure lowering. The effect is typically mild but can cause dizziness in susceptible patients.
What this interaction means in plain words
Sildenafil and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sildenafil belongs to Genitourinary; Timolol belongs to Cardiovascular.
Why it happens
Additive hypotension from PDE5 inhibition and beta-blockade.
What to do
Monitor blood pressure after starting sildenafil and counsel on orthostatic symptoms. Use a low initial sildenafil dose in patients with low baseline blood pressure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Sildenafil and Timolol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Sildenafil with Timolol?
MediHelp rates the interaction as minor. Sildenafil and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic timolol (including some absorption from eye drops) may add to sildenafil's blood pressure lowering. The effect is typically mild but can cause dizziness in susceptible patients.
How serious is the interaction between Sildenafil and Timolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting sildenafil and counsel on orthostatic symptoms. Use a low initial sildenafil dose in patients with low baseline blood pressure.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
