Drug interactions
Siponimod + Telotristat ethyl
Severity: Moderate
Siponimod and Telotristat ethyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telotristat may reduce CYP3A4 substrate exposure and could lower siponimod concentrations. This may reduce efficacy, particularly in patients with reduced CYP2C9 activity.
What this interaction means in plain words
Siponimod and Telotristat ethyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Telotristat is reported to induce CYP3A4, increasing siponimod metabolism.
What to do
Monitor for reduced multiple sclerosis disease control. Avoid in patients with CYP2C9*1/*3 or *2/*3 genotype.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Frequently asked questions
Can I take Siponimod with Telotristat ethyl?
MediHelp rates the interaction as moderate. Siponimod and Telotristat ethyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Telotristat may reduce CYP3A4 substrate exposure and could lower siponimod concentrations. This may reduce efficacy, particularly in patients with reduced CYP2C9 activity.
How serious is the interaction between Siponimod and Telotristat ethyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced multiple sclerosis disease control. Avoid in patients with CYP2C9*1/*3 or *2/*3 genotype.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Cladribine, Fingolimod, Fluconazole. The full list is on the Siponimod page.
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