Drug interactions
Siponimod + Tetanus and reduced diphtheria toxoids / acellular pertussis vaccine
Severity: Minor
Siponimod and Tetanus and reduced diphtheria toxoids / acellular pertussis vaccine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This is a non-live vaccine, so there is no risk of vaccine-strain infection. Siponimod may weaken the immune response.
What this interaction means in plain words
Siponimod and Tetanus and reduced diphtheria toxoids / acellular pertussis vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Siponimod-induced lymphocyte sequestration may blunt vaccine antibody responses.
What to do
Vaccinate when indicated; ideally give it at least 1 week before starting siponimod. Do not delay needed vaccination for wound or outbreak indications.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Siponimod and Tetanus and reduced diphtheria toxoids / acellular pertussis vaccine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Frequently asked questions
Can I take Siponimod with Tetanus and reduced diphtheria toxoids / acellular pertussis vaccine?
MediHelp rates the interaction as minor. Siponimod and Tetanus and reduced diphtheria toxoids / acellular pertussis vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. This is a non-live vaccine, so there is no risk of vaccine-strain infection. Siponimod may weaken the immune response.
How serious is the interaction between Siponimod and Tetanus and reduced diphtheria toxoids / acellular pertussis vaccine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate when indicated; ideally give it at least 1 week before starting siponimod. Do not delay needed vaccination for wound or outbreak indications.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Cladribine, Fingolimod, Fluconazole. The full list is on the Siponimod page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
