Drug interactions
Sodium picosulfate / magnesium oxide / anhydrous citric acid + Tolmetin
Severity: Moderate
Sodium picosulfate / magnesium oxide / anhydrous citric acid and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bowel preparations cause fluid loss and electrolyte shifts, and NSAIDs reduce renal perfusion. Together they increase the risk of acute kidney injury, particularly with dehydration.
What this interaction means in plain words
Sodium picosulfate / magnesium oxide / anhydrous citric acid and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Volume depletion from bowel cleansing combined with NSAID-induced inhibition of renal prostaglandins impairs renal blood flow.
What to do
Withhold tolmetin on the day of bowel preparation where possible and ensure adequate oral fluid intake. Check renal function and electrolytes in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Sodium picosulfate / magnesium oxide / anhydrous citric acid with Tolmetin?
MediHelp rates the interaction as moderate. Sodium picosulfate / magnesium oxide / anhydrous citric acid and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bowel preparations cause fluid loss and electrolyte shifts, and NSAIDs reduce renal perfusion. Together they increase the risk of acute kidney injury, particularly with dehydration.
How serious is the interaction between Sodium picosulfate / magnesium oxide / anhydrous citric acid and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Withhold tolmetin on the day of bowel preparation where possible and ensure adequate oral fluid intake. Check renal function and electrolytes in high-risk patients.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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