Drug interactions
Sodium sulfate / ?magnesium sulfate / potassium chloride + Tolmetin
Severity: Moderate
Sodium sulfate / ?magnesium sulfate / potassium chloride and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osmotic bowel preparations cause fluid and electrolyte disturbances, and NSAIDs can impair renal function. Together the risk of acute kidney injury and electrolyte-related events such as arrhythmias or seizures may rise.
What this interaction means in plain words
Sodium sulfate / ?magnesium sulfate / potassium chloride and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Preparation-induced volume depletion and electrolyte shifts combined with NSAID reduction of renal prostaglandin-mediated perfusion.
What to do
Avoid NSAIDs during bowel preparation if feasible and maintain hydration. Measure renal function and electrolytes in patients at risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Sodium sulfate / ?magnesium sulfate / potassium chloride with Tolmetin?
MediHelp rates the interaction as moderate. Sodium sulfate / ?magnesium sulfate / potassium chloride and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osmotic bowel preparations cause fluid and electrolyte disturbances, and NSAIDs can impair renal function. Together the risk of acute kidney injury and electrolyte-related events such as arrhythmias or seizures may rise.
How serious is the interaction between Sodium sulfate / ?magnesium sulfate / potassium chloride and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs during bowel preparation if feasible and maintain hydration. Measure renal function and electrolytes in patients at risk.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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