Drug interactions
Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol + Tolmetin
Severity: Moderate
Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bowel preparations can cause dehydration and electrolyte imbalance, and NSAIDs can reduce renal perfusion and promote water retention with hyponatremia. The combination raises the risk of kidney injury and electrolyte disturbance.
What this interaction means in plain words
Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Volume depletion and electrolyte shifts from the preparation combined with NSAID inhibition of renal prostaglandins and effects on water handling.
What to do
Hold tolmetin during bowel preparation where possible and encourage clear fluid intake. Check sodium, potassium and creatinine in vulnerable patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol with Tolmetin?
MediHelp rates the interaction as moderate. Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bowel preparations can cause dehydration and electrolyte imbalance, and NSAIDs can reduce renal perfusion and promote water retention with hyponatremia. The combination raises the risk of kidney injury and electrolyte disturbance.
How serious is the interaction between Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold tolmetin during bowel preparation where possible and encourage clear fluid intake. Check sodium, potassium and creatinine in vulnerable patients.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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