Drug interactions
Sodium sulfate / potassium sulfate / magnesium sulfate + Streptomycin
Severity: Moderate
Sodium sulfate / potassium sulfate / magnesium sulfate and Streptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osmotic bowel preparations can cause fluid loss and electrolyte disturbance, and volume depletion increases the risk of kidney injury. Streptomycin is nephrotoxic and ototoxic and is cleared renally, so dehydration may raise its exposure and toxicity. Magnesium may also add to aminoglycoside neuromuscular effects.
What this interaction means in plain words
Sodium sulfate / potassium sulfate / magnesium sulfate and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Volume depletion and electrolyte shifts impair renal function and reduce aminoglycoside clearance, with possible additive neuromuscular effects of magnesium.
What to do
Ensure adequate hydration and check renal function and electrolytes around the bowel preparation. Consider timing the preparation away from streptomycin doses or reducing the dose in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Sodium sulfate / potassium sulfate / magnesium sulfate and Streptomycin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Streptomycin
Frequently asked questions
Can I take Sodium sulfate / potassium sulfate / magnesium sulfate with Streptomycin?
MediHelp rates the interaction as moderate. Sodium sulfate / potassium sulfate / magnesium sulfate and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osmotic bowel preparations can cause fluid loss and electrolyte disturbance, and volume depletion increases the risk of kidney injury. Streptomycin is nephrotoxic and ototoxic and is cleared renally, so dehydration may raise its exposure and toxicity. Magnesium may also add to aminoglycoside neuromuscular effects.
How serious is the interaction between Sodium sulfate / potassium sulfate / magnesium sulfate and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and check renal function and electrolytes around the bowel preparation. Consider timing the preparation away from streptomycin doses or reducing the dose in renal impairment.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
