Drug interactions
Sofosbuvir-velpatasvir + Sulbactam / durlobactam
Severity: Minor
Sofosbuvir-velpatasvir and Sulbactam / durlobactam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulbactam is cleared partly by OAT1-mediated secretion, and inhibition of this transporter could raise its levels. Sofosbuvir and velpatasvir are not well-established OAT1 inhibitors, so no clinically significant effect is expected.
What this interaction means in plain words
Sofosbuvir-velpatasvir and Sulbactam / durlobactam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible OAT1 inhibition could reduce renal secretion of sulbactam, but this is theoretical.
What to do
No dose adjustment is needed. Monitor for beta-lactam adverse effects as for routine therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Frequently asked questions
Can I take Sofosbuvir-velpatasvir with Sulbactam / durlobactam?
MediHelp rates the interaction as minor. Sofosbuvir-velpatasvir and Sulbactam / durlobactam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulbactam is cleared partly by OAT1-mediated secretion, and inhibition of this transporter could raise its levels. Sofosbuvir and velpatasvir are not well-established OAT1 inhibitors, so no clinically significant effect is expected.
How serious is the interaction between Sofosbuvir-velpatasvir and Sulbactam / durlobactam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for beta-lactam adverse effects as for routine therapy.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
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