Drug interactions
Sofosbuvir-velpatasvir + Sulfasalazine
Severity: Minor
Sofosbuvir-velpatasvir and Sulfasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine is a BCRP substrate, and velpatasvir inhibits BCRP, which may raise systemic sulfasalazine exposure. Clinical effects such as gastrointestinal upset or hematologic toxicity are possible but unlikely to be large.
What this interaction means in plain words
Sofosbuvir-velpatasvir and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Velpatasvir inhibits intestinal BCRP, reducing efflux of sulfasalazine.
What to do
Monitor for adverse effects such as nausea, rash and blood count changes. No dose adjustment is required routinely.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Frequently asked questions
Can I take Sofosbuvir-velpatasvir with Sulfasalazine?
MediHelp rates the interaction as minor. Sofosbuvir-velpatasvir and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfasalazine is a BCRP substrate, and velpatasvir inhibits BCRP, which may raise systemic sulfasalazine exposure. Clinical effects such as gastrointestinal upset or hematologic toxicity are possible but unlikely to be large.
How serious is the interaction between Sofosbuvir-velpatasvir and Sulfasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects such as nausea, rash and blood count changes. No dose adjustment is required routinely.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
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