Drug interactions
Sofosbuvir-velpatasvir + Tenofovir df
Severity: Moderate
Sofosbuvir-velpatasvir and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir inhibits P-gp and raises tenofovir exposure when tenofovir DF is used, particularly with boosted regimens. This increases the risk of renal toxicity and bone effects.
What this interaction means in plain words
Sofosbuvir-velpatasvir and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Velpatasvir inhibits intestinal P-gp, increasing tenofovir absorption and plasma concentrations.
What to do
Monitor renal function, including creatinine clearance, urine glucose and protein, at baseline and during treatment. Consider tenofovir alafenamide in patients with renal risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Frequently asked questions
Can I take Sofosbuvir-velpatasvir with Tenofovir df?
MediHelp rates the interaction as moderate. Sofosbuvir-velpatasvir and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Velpatasvir inhibits P-gp and raises tenofovir exposure when tenofovir DF is used, particularly with boosted regimens. This increases the risk of renal toxicity and bone effects.
How serious is the interaction between Sofosbuvir-velpatasvir and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, including creatinine clearance, urine glucose and protein, at baseline and during treatment. Consider tenofovir alafenamide in patients with renal risk.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
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