Drug interactions
Sofosbuvir / velpatasvir + Valsartan
Severity: Minor
Sofosbuvir / velpatasvir and Valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir inhibits OATP1B1, OATP1B3 and OATP2B1, which can raise exposure to substrates such as valsartan. Greater exposure could cause hypotension or renal effects, though clinical significance appears limited.
What this interaction means in plain words
Sofosbuvir / velpatasvir and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of OATP-mediated hepatic uptake of valsartan by velpatasvir.
What to do
Monitor blood pressure after starting the antiviral regimen and reduce valsartan dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Sofosbuvir / velpatasvir with Valsartan?
MediHelp rates the interaction as minor. Sofosbuvir / velpatasvir and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Velpatasvir inhibits OATP1B1, OATP1B3 and OATP2B1, which can raise exposure to substrates such as valsartan. Greater exposure could cause hypotension or renal effects, though clinical significance appears limited.
How serious is the interaction between Sofosbuvir / velpatasvir and Valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting the antiviral regimen and reduce valsartan dose if hypotension occurs.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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