Drug interactions
Somapacitan + Theophylline
Severity: Minor
Somapacitan and Theophylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone therapy may increase cytochrome P450 activity, which could speed up theophylline metabolism and reduce its concentrations. The data are limited, but theophylline's narrow therapeutic index makes this relevant.
What this interaction means in plain words
Somapacitan and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Somapacitan belongs to Endocrine; Theophylline belongs to Respiratory.
Why it happens
Growth hormone may induce CYP1A2 and CYP3A4, increasing theophylline clearance.
What to do
Check theophylline levels if there is reduced clinical effect after somapacitan is started, and adjust the dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Somapacitan
- Alogliptin-metformin + Somapacitan Moderate
- Alogliptin-pioglitazone + Somapacitan Moderate
- Alogliptin + Somapacitan Moderate
- Bazedoxifene-conjugated estrogens + Somapacitan Moderate
- Canagliflozin-metformin + Somapacitan Moderate
- Chlorpropamide + Somapacitan Moderate
Frequently asked questions
Can I take Somapacitan with Theophylline?
MediHelp rates the interaction as minor. Somapacitan and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Growth hormone therapy may increase cytochrome P450 activity, which could speed up theophylline metabolism and reduce its concentrations. The data are limited, but theophylline's narrow therapeutic index makes this relevant.
How serious is the interaction between Somapacitan and Theophylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check theophylline levels if there is reduced clinical effect after somapacitan is started, and adjust the dose as needed.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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