Drug interactions
Sorafenib + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Sorafenib and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sorafenib prolongs QT and vilanterol, a beta-agonist, can have cardiovascular effects including QT prolongation and tachycardia. Inhaled systemic exposure is low, so concern mainly applies to patients with cardiac risk factors.
What this interaction means in plain words
Sorafenib and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization.
What to do
Monitor ECG and electrolytes in at-risk patients and keep the inhaler at the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Frequently asked questions
Can I take Sorafenib with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Sorafenib and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sorafenib prolongs QT and vilanterol, a beta-agonist, can have cardiovascular effects including QT prolongation and tachycardia. Inhaled systemic exposure is low, so concern mainly applies to patients with cardiac risk factors.
How serious is the interaction between Sorafenib and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes in at-risk patients and keep the inhaler at the lowest effective dose.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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