Drug interactions
Sotorasib + Tenofovir disoproxil
Severity: Minor
Sotorasib and Tenofovir disoproxil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib inhibits P-gp and may increase exposure to P-gp substrates; the legacy claim of decreased tenofovir levels is not consistent with this. Tenofovir exposure could modestly rise, with uncertain clinical effect.
What this interaction means in plain words
Sotorasib and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible P-gp inhibition increasing tenofovir absorption.
What to do
No routine dose change is needed. Monitor renal function and tenofovir-related adverse effects during co-therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Sotorasib with Tenofovir disoproxil?
MediHelp rates the interaction as minor. Sotorasib and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sotorasib inhibits P-gp and may increase exposure to P-gp substrates; the legacy claim of decreased tenofovir levels is not consistent with this. Tenofovir exposure could modestly rise, with uncertain clinical effect.
How serious is the interaction between Sotorasib and Tenofovir disoproxil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor renal function and tenofovir-related adverse effects during co-therapy.
What other medicines interact with Sotorasib?
MediHelp also lists interactions of Sotorasib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Sotorasib page.
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