Drug interactions
Spironolactone + Sulfasalazine
Severity: Minor
Spironolactone and Sulfasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents have been associated with hyperkalemia, although sulfasalazine rarely does so on its own. The combination is unlikely to cause problems in most patients but may matter in those with renal impairment.
What this interaction means in plain words
Spironolactone and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Spironolactone reduces renal potassium excretion; the contribution of sulfasalazine (possibly via rare renal effects) is poorly established.
What to do
Monitor serum potassium and renal function periodically in patients with kidney disease or other risk factors for hyperkalemia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Spironolactone with Sulfasalazine?
MediHelp rates the interaction as minor. Spironolactone and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both agents have been associated with hyperkalemia, although sulfasalazine rarely does so on its own. The combination is unlikely to cause problems in most patients but may matter in those with renal impairment.
How serious is the interaction between Spironolactone and Sulfasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function periodically in patients with kidney disease or other risk factors for hyperkalemia.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
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