Drug interactions
Spironolactone + Terbutaline
Severity: Minor
Spironolactone and Terbutaline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Terbutaline lowers serum potassium by driving it into cells while spironolactone promotes potassium retention. The effects largely offset each other, but potassium may vary in renal impairment.
What this interaction means in plain words
Spironolactone and Terbutaline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Spironolactone belongs to Cardiovascular; Terbutaline belongs to Respiratory.
Why it happens
Beta2-mediated potassium shift opposes aldosterone antagonism-related potassium retention.
What to do
No routine adjustment is needed. Monitor potassium in renal impairment, heart failure or with high-dose or parenteral terbutaline.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Terbutaline
Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Spironolactone with Terbutaline?
MediHelp rates the interaction as minor. Spironolactone and Terbutaline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Terbutaline lowers serum potassium by driving it into cells while spironolactone promotes potassium retention. The effects largely offset each other, but potassium may vary in renal impairment.
How serious is the interaction between Spironolactone and Terbutaline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor potassium in renal impairment, heart failure or with high-dose or parenteral terbutaline.
What other medicines interact with Terbutaline?
MediHelp also lists interactions of Terbutaline with, for example, Carvedilol, Droperidol, Fexinidazole. The full list is on the Terbutaline page.
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