Drug interactions
spironolactone + trimethoprim-sulfamethoxazole
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Severe hyperkalemia risk.
Mechanism of action
Trimethoprim is potassium-sparing.
Clinical management
Avoid; monitor K⁺ closely if unavoidable.
Drug reference
References
Frequently asked questions
Can I take spironolactone with trimethoprim-sulfamethoxazole?
The interaction is rated: Major. Severe hyperkalemia risk.
How serious is the interaction between spironolactone and trimethoprim-sulfamethoxazole?
The interaction is rated: Major. Evidence level: High.
How is the interaction between spironolactone and trimethoprim-sulfamethoxazole managed?
Avoid; monitor K⁺ closely if unavoidable.
Why do spironolactone and trimethoprim-sulfamethoxazole interact?
Trimethoprim is potassium-sparing.
Full monographs, dosing and an interaction checker in the MediHelp app
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