Drug interactions
Spironolactone + Xipamide
Severity: Moderate
Spironolactone and Xipamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Xipamide, a thiazide-like diuretic, and spironolactone act at different nephron sites and produce additive diuresis and blood pressure lowering. The combination is often used deliberately, but it can lead to volume depletion, hypotension and electrolyte disturbance, although spironolactone offsets xipamide-related potassium loss.
What this interaction means in plain words
Spironolactone and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sequential nephron blockade with additive natriuretic and antihypertensive effects.
What to do
Monitor blood pressure, volume status, sodium, potassium and renal function after starting or adjusting either drug. Reduce doses if hypotension or electrolyte abnormalities occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Spironolactone with Xipamide?
MediHelp rates the interaction as moderate. Spironolactone and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Xipamide, a thiazide-like diuretic, and spironolactone act at different nephron sites and produce additive diuresis and blood pressure lowering. The combination is often used deliberately, but it can lead to volume depletion, hypotension and electrolyte disturbance, although spironolactone offsets xipamide-related potassium loss.
How serious is the interaction between Spironolactone and Xipamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, volume status, sodium, potassium and renal function after starting or adjusting either drug. Reduce doses if hypotension or electrolyte abnormalities occur.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
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