Drug interactions
St john's wort + Triamcinolone
Severity: Moderate
St john's wort and Triamcinolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
St John's wort induces CYP3A4 and may reduce triamcinolone exposure, weakening its therapeutic effect. The impact is greatest with regular herbal use and may be less predictable with depot injections.
What this interaction means in plain words
St john's wort and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 (and P-glycoprotein) by hyperforin increases triamcinolone clearance.
What to do
Ask patients about herbal use and advise stopping St John's wort where feasible. Monitor response and adjust the corticosteroid dose if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamcinolone
- Smallpox vaccine live + Triamcinolone Contraindicated
- Triamcinolone + Zoster vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Triamcinolone Major
- Aldesleukin + Triamcinolone Major
- Atazanavir + Triamcinolone Major
- Axicabtagene ciloleucel + Triamcinolone Major
Frequently asked questions
Can I take St john's wort with Triamcinolone?
MediHelp rates the interaction as moderate. St john's wort and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. St John's wort induces CYP3A4 and may reduce triamcinolone exposure, weakening its therapeutic effect. The impact is greatest with regular herbal use and may be less predictable with depot injections.
How serious is the interaction between St john's wort and Triamcinolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients about herbal use and advise stopping St John's wort where feasible. Monitor response and adjust the corticosteroid dose if control is lost.
What other medicines interact with Triamcinolone?
MediHelp also lists interactions of Triamcinolone with, for example, Smallpox vaccine live, Zoster vaccine live, Adenovirus types 4 and 7 live. The full list is on the Triamcinolone page.
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