Drug interactions
Streptomycin + Tenofovir df
Severity: Moderate
Streptomycin and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir disoproxil can cause proximal renal tubular injury, and streptomycin is also nephrotoxic. Together they increase the chance of kidney impairment, which further raises aminoglycoside levels and ototoxicity risk.
What this interaction means in plain words
Streptomycin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal tubular toxicity, with impaired renal elimination of both drugs when kidney function declines.
What to do
Monitor serum creatinine, phosphate and urinalysis regularly during co-therapy, and adjust streptomycin dosing to renal function. Consider an alternative antiretroviral if renal function deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Streptomycin
Frequently asked questions
Can I take Streptomycin with Tenofovir df?
MediHelp rates the interaction as moderate. Streptomycin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir disoproxil can cause proximal renal tubular injury, and streptomycin is also nephrotoxic. Together they increase the chance of kidney impairment, which further raises aminoglycoside levels and ototoxicity risk.
How serious is the interaction between Streptomycin and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, phosphate and urinalysis regularly during co-therapy, and adjust streptomycin dosing to renal function. Consider an alternative antiretroviral if renal function deteriorates.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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