Drug interactions
Streptomycin + Tenofovir disoproxil
Severity: Major
Streptomycin and Tenofovir disoproxil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Streptomycin is an aminoglycoside that is nephrotoxic and ototoxic and is eliminated by the kidney. Combined with tenofovir, the risk of renal injury increases, and reduced renal function may raise exposure to both drugs.
What this interaction means in plain words
Streptomycin and Tenofovir disoproxil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity with reduced renal elimination of both drugs.
What to do
Monitor serum creatinine, phosphate and streptomycin levels frequently, and assess hearing and vestibular function. Use an alternative antiretroviral if renal function declines.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Streptomycin
Frequently asked questions
Can I take Streptomycin with Tenofovir disoproxil?
MediHelp rates the interaction as major. Streptomycin and Tenofovir disoproxil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Streptomycin is an aminoglycoside that is nephrotoxic and ototoxic and is eliminated by the kidney. Combined with tenofovir, the risk of renal injury increases, and reduced renal function may raise exposure to both drugs.
How serious is the interaction between Streptomycin and Tenofovir disoproxil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, phosphate and streptomycin levels frequently, and assess hearing and vestibular function. Use an alternative antiretroviral if renal function declines.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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