Drug interactions
Streptomycin + Ticarcillin
Severity: Moderate
Streptomycin and Ticarcillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Penicillins such as ticarcillin can chemically inactivate aminoglycosides in vitro, and in patients with severe renal impairment this may lower measured and effective streptomycin levels. The effect matters mainly when samples are stored with the penicillin or when clearance of both drugs is greatly reduced.
What this interaction means in plain words
Streptomycin and Ticarcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nucleophilic opening of the beta-lactam ring inactivates the aminoglycoside, mainly in vitro or in renal failure where both drugs persist.
What to do
Give the two drugs at separate sites and times, and in renal failure monitor streptomycin levels and clinical response. Process serum samples promptly or freeze them to avoid in-tube inactivation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Streptomycin
Frequently asked questions
Can I take Streptomycin with Ticarcillin?
MediHelp rates the interaction as moderate. Streptomycin and Ticarcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Penicillins such as ticarcillin can chemically inactivate aminoglycosides in vitro, and in patients with severe renal impairment this may lower measured and effective streptomycin levels. The effect matters mainly when samples are stored with the penicillin or when clearance of both drugs is greatly reduced.
How serious is the interaction between Streptomycin and Ticarcillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the two drugs at separate sites and times, and in renal failure monitor streptomycin levels and clinical response. Process serum samples promptly or freeze them to avoid in-tube inactivation.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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