Drug interactions
Streptomycin + Tobramycin inhaled
Severity: Moderate
Streptomycin and Tobramycin inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two aminoglycosides given together increase the risk of cumulative ototoxicity and nephrotoxicity. Inhaled tobramycin has limited systemic absorption, but exposure can rise with renal impairment.
What this interaction means in plain words
Streptomycin and Tobramycin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive aminoglycoside toxicity to the cochlea, vestibular system and renal tubules.
What to do
Avoid concurrent or overlapping courses where possible. If both are needed, monitor renal function and hearing and consider drug level monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Streptomycin
Frequently asked questions
Can I take Streptomycin with Tobramycin inhaled?
MediHelp rates the interaction as moderate. Streptomycin and Tobramycin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Two aminoglycosides given together increase the risk of cumulative ototoxicity and nephrotoxicity. Inhaled tobramycin has limited systemic absorption, but exposure can rise with renal impairment.
How serious is the interaction between Streptomycin and Tobramycin inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent or overlapping courses where possible. If both are needed, monitor renal function and hearing and consider drug level monitoring.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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