Drug interactions
Sulfasalazine + Valsartan
Severity: Minor
Sulfasalazine and Valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine is not a typical NSAID and its systemic prostaglandin effect is small, so a meaningful interaction with valsartan is not well established. Renal function and potassium monitoring are reasonable in vulnerable patients.
What this interaction means in plain words
Sulfasalazine and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No well-established mechanism; a weak prostaglandin-related renal effect is theoretical.
What to do
No routine adjustment is needed. Monitor renal function and potassium in elderly or volume-depleted patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Sulfasalazine with Valsartan?
MediHelp rates the interaction as minor. Sulfasalazine and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfasalazine is not a typical NSAID and its systemic prostaglandin effect is small, so a meaningful interaction with valsartan is not well established. Renal function and potassium monitoring are reasonable in vulnerable patients.
How serious is the interaction between Sulfasalazine and Valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor renal function and potassium in elderly or volume-depleted patients.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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