Drug interactions
Sulfisoxazole + Tretinoin
Severity: Moderate
Sulfisoxazole and Tretinoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfisoxazole, like other sulfonamides, can sensitize skin to light, and tretinoin independently increases photosensitivity. Together they may produce more pronounced sunburn or phototoxic rashes.
What this interaction means in plain words
Sulfisoxazole and Tretinoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive photosensitizing effects of a retinoid and a sulfonamide.
What to do
Advise sun protection and avoidance of tanning devices during co-treatment. Reduce tretinoin frequency or interrupt it if phototoxic reactions appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tretinoin
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
Frequently asked questions
Can I take Sulfisoxazole with Tretinoin?
MediHelp rates the interaction as moderate. Sulfisoxazole and Tretinoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfisoxazole, like other sulfonamides, can sensitize skin to light, and tretinoin independently increases photosensitivity. Together they may produce more pronounced sunburn or phototoxic rashes.
How serious is the interaction between Sulfisoxazole and Tretinoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise sun protection and avoidance of tanning devices during co-treatment. Reduce tretinoin frequency or interrupt it if phototoxic reactions appear.
What other medicines interact with Tretinoin?
MediHelp also lists interactions of Tretinoin with, for example, Doxycycline, Minocycline, Omadacycline. The full list is on the Tretinoin page.
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