Drug interactions
Sulphasalazine + Valoctocogene roxaparvovec
Severity: Moderate
Sulphasalazine and Valoctocogene roxaparvovec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valoctocogene roxaparvovec commonly causes transaminase elevations, and sulfasalazine can also be hepatotoxic. Combined use may increase the risk or severity of liver injury and may compromise gene therapy efficacy if immunosuppression is required.
What this interaction means in plain words
Sulphasalazine and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sulphasalazine belongs to Gastrointestinal Tract; Valoctocogene roxaparvovec belongs to Miscellaneous.
Why it happens
Additive hepatotoxicity potential of two agents that can raise liver enzymes.
What to do
Monitor ALT and other liver tests regularly during the post-infusion period. Consider an alternative to sulfasalazine if liver enzymes rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Acetazolamide + Sulphasalazine Moderate
Other interactions of Valoctocogene roxaparvovec
Frequently asked questions
Can I take Sulphasalazine with Valoctocogene roxaparvovec?
MediHelp rates the interaction as moderate. Sulphasalazine and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valoctocogene roxaparvovec commonly causes transaminase elevations, and sulfasalazine can also be hepatotoxic. Combined use may increase the risk or severity of liver injury and may compromise gene therapy efficacy if immunosuppression is required.
How serious is the interaction between Sulphasalazine and Valoctocogene roxaparvovec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ALT and other liver tests regularly during the post-infusion period. Consider an alternative to sulfasalazine if liver enzymes rise.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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