Drug interactions
Sulphasalazine + Zavegepant intranasal
Severity: Moderate
Sulphasalazine and Zavegepant intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zavegepant is a substrate of the hepatic uptake transporter NTCP, and sulfasalazine is reported to inhibit NTCP. Co-administration may raise systemic zavegepant exposure, although the clinical consequences of this increase have not been well characterized.
What this interaction means in plain words
Sulphasalazine and Zavegepant intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of NTCP-mediated hepatic uptake of zavegepant reduces its clearance and increases systemic exposure.
What to do
Consider an alternative acute migraine treatment if the patient takes sulfasalazine regularly. If both are used, monitor for zavegepant adverse effects such as nasal discomfort, taste disturbance and nausea.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Acetazolamide + Sulphasalazine Moderate
Frequently asked questions
Can I take Sulphasalazine with Zavegepant intranasal?
MediHelp rates the interaction as moderate. Sulphasalazine and Zavegepant intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zavegepant is a substrate of the hepatic uptake transporter NTCP, and sulfasalazine is reported to inhibit NTCP. Co-administration may raise systemic zavegepant exposure, although the clinical consequences of this increase have not been well characterized.
How serious is the interaction between Sulphasalazine and Zavegepant intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative acute migraine treatment if the patient takes sulfasalazine regularly. If both are used, monitor for zavegepant adverse effects such as nasal discomfort, taste disturbance and nausea.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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