Drug interactions
Sunitinib + Topiramate
Severity: Minor
Sunitinib and Topiramate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sunitinib is metabolised by CYP3A4, and inducers can lower exposure of sunitinib and its active metabolite. Topiramate is a weak inducer, so the reduction is likely small.
What this interaction means in plain words
Sunitinib and Topiramate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sunitinib belongs to Oncology; Topiramate belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction by topiramate may increase sunitinib clearance.
What to do
No empirical dose adjustment is needed; monitor treatment response and adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Topiramate
Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Sunitinib with Topiramate?
MediHelp rates the interaction as minor. Sunitinib and Topiramate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sunitinib is metabolised by CYP3A4, and inducers can lower exposure of sunitinib and its active metabolite. Topiramate is a weak inducer, so the reduction is likely small.
How serious is the interaction between Sunitinib and Topiramate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose adjustment is needed; monitor treatment response and adverse effects.
What other medicines interact with Topiramate?
MediHelp also lists interactions of Topiramate with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Topiramate page.
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