Drug interactions
Sunitinib + Trifluoperazine
Severity: Moderate
Sunitinib and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are associated with QT prolongation, so the combination may increase the risk of torsades de pointes. Phenothiazines can also cause hypotension and sedation.
What this interaction means in plain words
Sunitinib and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive prolongation of cardiac repolarization via QT effects.
What to do
Obtain a baseline ECG and monitor ECG and electrolytes, correcting potassium and magnesium. Consider an antipsychotic with lower QT liability if QTc rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Sunitinib with Trifluoperazine?
MediHelp rates the interaction as moderate. Sunitinib and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are associated with QT prolongation, so the combination may increase the risk of torsades de pointes. Phenothiazines can also cause hypotension and sedation.
How serious is the interaction between Sunitinib and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor ECG and electrolytes, correcting potassium and magnesium. Consider an antipsychotic with lower QT liability if QTc rises.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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