Drug interactions
Sunitinib + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Sunitinib and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a long-acting beta agonist, can affect cardiac repolarization and heart rate. Sunitinib prolongs QT, so the combination might add to arrhythmia risk, though inhaled systemic exposure is low.
What this interaction means in plain words
Sunitinib and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QTc and cardiovascular effects.
What to do
Monitor ECG in patients with cardiac risk factors. Correct potassium and magnesium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Sunitinib with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Sunitinib and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol, a long-acting beta agonist, can affect cardiac repolarization and heart rate. Sunitinib prolongs QT, so the combination might add to arrhythmia risk, though inhaled systemic exposure is low.
How serious is the interaction between Sunitinib and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with cardiac risk factors. Correct potassium and magnesium.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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