Drug interactions
Synthetic human angiotensin ii + Trandolapril
Severity: Moderate
Synthetic human angiotensin ii and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin II is a vasopressor, and ACE inhibitors reduce its formation from angiotensin I. Patients on ACE inhibitors may show an increased pressor response to infused angiotensin II, so lower starting doses may be needed.
What this interaction means in plain words
Synthetic human angiotensin ii and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ACE inhibition reduces endogenous angiotensin II, which may heighten responsiveness to exogenous angiotensin II.
What to do
Titrate angiotensin II infusion carefully from a low dose with continuous blood pressure monitoring. Adjust the infusion rate to the response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Synthetic human angiotensin ii and Trandolapril, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Frequently asked questions
Can I take Synthetic human angiotensin ii with Trandolapril?
MediHelp rates the interaction as moderate. Synthetic human angiotensin ii and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angiotensin II is a vasopressor, and ACE inhibitors reduce its formation from angiotensin I. Patients on ACE inhibitors may show an increased pressor response to infused angiotensin II, so lower starting doses may be needed.
How serious is the interaction between Synthetic human angiotensin ii and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate angiotensin II infusion carefully from a low dose with continuous blood pressure monitoring. Adjust the infusion rate to the response.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
