Drug interactions
Synthetic human angiotensin ii + Valsartan
Severity: Moderate
Synthetic human angiotensin ii and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan blocks the AT1 receptor and can reduce the pressor response to exogenous angiotensin II. In patients with septic or distributive shock, this could necessitate higher angiotensin II doses.
What this interaction means in plain words
Synthetic human angiotensin ii and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competitive AT1 receptor antagonism by valsartan opposes the vasoconstrictor action of angiotensin II.
What to do
Hold valsartan in patients receiving angiotensin II for shock. Titrate angiotensin II to blood pressure response if recent valsartan exposure is present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Synthetic human angiotensin ii with Valsartan?
MediHelp rates the interaction as moderate. Synthetic human angiotensin ii and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valsartan blocks the AT1 receptor and can reduce the pressor response to exogenous angiotensin II. In patients with septic or distributive shock, this could necessitate higher angiotensin II doses.
How serious is the interaction between Synthetic human angiotensin ii and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold valsartan in patients receiving angiotensin II for shock. Titrate angiotensin II to blood pressure response if recent valsartan exposure is present.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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