Drug interactions
Tadalafil + Telmisartan-amlodipine
Severity: Moderate
Tadalafil and Telmisartan-amlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tadalafil has vasodilating properties and can add to the blood pressure lowering effect of telmisartan and amlodipine. Symptomatic hypotension, dizziness or syncope may occur, especially at the start of therapy.
What this interaction means in plain words
Tadalafil and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tadalafil belongs to Genitourinary; Telmisartan-amlodipine belongs to Cardiovascular.
Why it happens
Additive vasodilation from PDE5 inhibition and calcium channel blockade plus angiotensin receptor blockade.
What to do
Start tadalafil at a low dose in patients on antihypertensives and monitor blood pressure. Counsel patients to rise slowly and report dizziness or fainting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Frequently asked questions
Can I take Tadalafil with Telmisartan-amlodipine?
MediHelp rates the interaction as moderate. Tadalafil and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tadalafil has vasodilating properties and can add to the blood pressure lowering effect of telmisartan and amlodipine. Symptomatic hypotension, dizziness or syncope may occur, especially at the start of therapy.
How serious is the interaction between Tadalafil and Telmisartan-amlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start tadalafil at a low dose in patients on antihypertensives and monitor blood pressure. Counsel patients to rise slowly and report dizziness or fainting.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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